This report is the Enterprise Architecture (EA) for the Ghana Health Service (GHS), which is a deliverable from the eGhana Enterprise Architecture project. The GHS Enterprise Architecture (EA) provides the framework for developing e-Health in Ghana. The GHS EA is more than just technology architecture. It involves primarily four architecture perspectives (Business Architecture, Applications Architecture, Data Architecture and Technical Architecture). The process of defining the Enterprise Architecture included defining relationships that depict how these architectures interrelate and will change as new events occur.