The Ugandan healthcare system, through its ongoing health sector reforms, aims to improve health outcomes. As part of these reforms, the Ministry of Health (MOH) developed the Health Sector Development Plan (HSDP) 2015/16 - 2019/20 to address the key challenges facing Uganda’s health system, set out priorities and key areas on which to focus health investment in the medium term, for both public and private partners, in order to optimally contribute to the attainment of both the health sector goals and the national goals as outlined in the National Development Plan II. Although implementation of HSSP III promised to produce many positive results, realizing the best outcomes in the face of increasing pressures on the healthcare system requires a fundamental transformation in the way health care is delivered and managed. The Ministry recognizes the potential of information and communication technology (ICT) in transforming healthcare delivery by enabling information access and supporting healthcare operations, management, and decision making. However, the Ugandan health sector is characterized by a fragmented landscape of ICT pilot projects and numerous data and health information system (HIS) silos with significant barriers to the effective sharing of information between healthcare participants.